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Clinical evidence shows that maintenance dosing with semaglutide produces measurable weight loss of 5-15% of body weight when combined with lifestyle modifications

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Collectively, we show that while GIPR agonism and antagonism have similar effects on body weight and food intake, they do so via different neuronal mechanisms, with GIPR antagonism, but not GIPR agonism, depending on GLP-1R signalling to affect energy metabolism