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This skepticism hampers widespread adoption, especially in mature markets where consumers are more discerning

No specific biomarker has yet been identified to correlate with tinnitus in the absence of hearing loss, suggesting that a future direction in this field should be to discover and validate such a biomarker

The increase in MDHAR activity has been reported in stress conditions like salinity, high light, UV radiation, boron toxicity and low temperature (Mittova et al., 2003

For example, bupropion/naltrexone has been studied for its effect on appetite control via the melanocortin system

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