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Cataract surgery is currently the only treatment for cataract-related vision impairment, with approximately 4 million procedures performed annually in the U.S

Other phytochemicals, including proanthocyanidins and naringenin, have been reported to suppress NLRP3 activation, decrease mtROS, and favor anti-inflammatory macrophage polarization in AP, again acting functionally at the interface between mitochondrial redox status, lysosomal integrity, and inflammasome assembly

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The stomach must also be able to produce enough stomach acid for optimal B12 absorption

Pharmacological inhibitors such as NLRP3 antagonists and caspase-1 inhibitors show promise in preclinical models but require further clinical validation

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