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Journal of Biological Chemistry Brachs et al
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NaBPC157 (10 g or 10 ng/kg i.p., i.g.) were investigated in rats in comparison with several reference standards in several experimental ulcer models (48 hour-restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests, NSAIAs-lesions, DNFB (Dinitrofluorhenzene), reflux esophagitis following esophagojejunal termino-lateral anastomosis) (pre-/co-/post-treatment)
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Additionally, IPA functions as an allosteric inhibitor of TrpE by mimicking tryptophan, blocking the catalytic step of tryptophan synthesis mediated by TrpE, thus disrupting metabolic pathways in pathogens such as Mycobacterium tuberculosis and suppressing their proliferation (91)
