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Oostenbrink C, Villa A, Mark AE, van Gunsteren WF (2004) A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

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This condition is defined by physiological and cognitive alterations that profoundly impair the persons ability to function, along with feelings of sorrow, emptiness or irritability