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Two were classified as recommended evidence, five as weak evidence, and 13 as poor evidence (Supplementary Table S6)

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The copper ion stabilizes the peptide structure, facilitates cellular uptake, and participates directly in the enzymatic reactions that promote collagen synthesis and tissue remodeling

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The twelve collected fractions were dialyzed against Tris buffer, examined in the electron microscope for the presence of nozzles using carbon-coated copper grids that were either glow-discharged or not, and analyzed using SDS-PAGE

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