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Meat (especially lamb) is a major dietary source of these compounds, which explains why some vegans are deficient in carnitine

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Falkenhain et al (170) found that 30 min after a single oral administration of 0.3 g/kg KME, blood -HB levels increased from 0.20.1 mM to 1.50.8 mM, reached a peak of 1.7-1.80.6 mM at 60-90 min and then decreased to 0.80.4 mM at 180 min

Tirzepatide is also less effective at reducing body weight in T2D patients compared to patients without (15.7% weight loss, SURMOUNT-2 and 22.5% weight loss, SURMOUNT-1, respectively)