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The authors have investigated three treatments to correct metabolic abnormalities which have demonstrated improvement in behavior and/or metabolism, namely the combination of methylcobalamin (mB12) with low-dose folinic acid (LDFA) to treat oxidative stress in an open-label study (James et al., 1A demonstrates where these agents are believed to act within four major interconnected metabolic pathways that are known to be disrupted in ASD

Reconstituted solutions should not be frozen

Glutathione neutralizes free radicals that are known to break down collagen through oxidative stress

Its recommended that they be discontinued at least two months before trying to conceive

The regimen combines hCG with a 500-calorie a day diet the equivalent of two slices of lean turkey on whole wheat bread, one slice of cheese, some lettuce, a little mustard, an apple and one cup of skim milk

doi: 10.1038/s41467-020-18751-8 41 GasbjergLSRosenkildeMMMeierJJHolstJJKnopFK