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Their combined presence allows investigators to explore how signaling pathways related to matrix organization, vascular adaptation, cellular movement, and structural maintenance may interact

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Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

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Side effects are rare, generally mild, and may include occasional injection-site irritation, or mild nausea