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Bile is the main form of B 12 excretion

Oxidative stress and ROS alter ion transporters, which leads to changes in the second messenger system and primary calcium homeostasis, resulting in an increase in calcium influx into the cytoplasm

These are outcomes that change health trajectories, reduce comorbidity risks, and fundamentally alter quality of life

Furthermore, NRF2 activation modulates epigenetic mechanisms in HSCs

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