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Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

ClinicalTrials.gov (2010)

Nitrosative stress and transcription

Literature data indicate that PWS patients have lower birth weight and a higher prevalence of preterm delivery and SGA ( Thyroid disorders are quite common in these individuals, and the dysregulation of the hypothalamic-pituitary-thyroid axis is the most frequent cause ( Supplementary Table 1 )

For example, in breast carcinomas, 8-OHdG has been reported to be increased 8- to 17-fold in breast primary tumors compared with nonmalignant breast tissue [79-81]