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Uday Juyal for his contribution in providing graphical assistance for this manuscript

These models help researchers explore how cells maintain functional stability during environmental or biological stress

When each resistant population was treated with MCFG, CO23RFK cells showed a moderate decrease of GSH/GSSG ratio indicating a slight oxidative stress while CO23RFLC cells were dramatically affected in the their oxidative state

We also demonstrate that mitochondrial metabolism may have a role in modulating both intrinsic and acquired 5FU resistance

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A number of studies have shown chromosome and spindle misalignments and aneuploidy in oocytes of mice exposed to ROS (7074)