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Consider two people who both lose 15 kilograms on a GLP-1 drug: Lost 15 kg but poorly 10 kg fat lost 5 kg muscle lost Metabolic rate has fallen Blood sugar control worsened Higher fall risk than before Weight regain likely as fat Lost 15 kg and well 14 kg fat lost 1 kg muscle lost (or neutral) Metabolic rate preserved Blood sugar control improved Strength maintained or increased Better long-term weight maintenance Both people lost the same amount of weight by the scale

CrossRef Early cancer risk reduction after GLP-1RA use: Signal or bias?: Letter to the editor on Glucagon-like peptide 1 receptor agonist and reduced liver and non-liver complications in adults with type 2 diabetes and metabolic dysfunction-associated steatotic l Shio-Shin Jean, Chih-Cheng Lai Clinical and Molecular Hepatology .2026

At 10mg/ml concentration, 5mg equals 50 units

We also approached the review with realistic expectations

You cant overdose on b12, your body will store any excess in the liver or excrete into your urine

Wrong peptide sequences may have entirely unpredictable effects