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(21) During the trial, 9 participants in the semaglutide group required dose reductions due to adverse effects

Contrave should not be taken with any other medications that contain bupropion

The FDA-approved Wegovy label, for example, describes semaglutide as a GLP-1 receptor agonist used with reduced calories and increased physical activity for long-term weight reduction in certain adults and adolescents, and for reducing risk of major cardiovascular events in certain adults with cardiovascular disease and overweight or obesity

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Whilst cortisol is essential for health, chronic elevation of cortisol levels can have detrimental effects