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And some people feel completely fine

However, nausea is the most commonly reported adverse effect, with incidence varying by medication and dose: approximately 15-30% for most GLP-1 agonists and up to 30-44% at higher doses of semaglutide and tirzepatide according to FDA prescribing information

These medicines are typically considered when metformin and other therapies have not achieved adequate glycaemic control, or when certain patient characteristics make them particularly suitablefor example, where weight loss is beneficial or cardiovascular or renal protection is a priority

Therefore, this review presents the triangle relationship of obesity, DM as well as cancer development and elucidates the treatment of overweight-associated T2DM with semaglutide, focusing on the question of whether the development of these conditions can be combated or if any severe side effects should be considered of this therapy

However, it is important to be cautious here: these are not head-to-head trials , and patient populations, trial durations, and protocols differ

By month 4 and beyond, most participants report feeling essentially normal with no regular nausea