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In the presence of GSH, GPX4 mediates the conversion of toxic LPOs to nontoxic lipid alcohols

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GSMe is usually a much weaker inhibitor in the HEDS assay or in assays with GSSR substrates 11,14,17 , suggesting that the competition between GSH and GSMe in the roGFP2 measurements occurred at the 1st and not the 2nd glutathione interaction site

But its important to have a clear understanding of the drugs risks before it can be safely prescribed