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Bupropion is metabolized primarily by CYP2B6, with active metabolites cleared by CYP2D6

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Peripherally administered CCK reduces food intake (123)

Furthermore, GLP-1 exhibits significant cardioprotective properties, particularly in pathological conditions, such as ischemia and myocardial damage

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That is the strongest evidence-based answer for when retatrutide clearly "works" in a clinical-trial sense: by 24 weeks, the higher-dose groups had separated sharply from placebo