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The STEP clinical trial program demonstrated that patients receiving weekly subcutaneous semaglutide achieved average weight loss of 1018% of body weight over 68 weeks, compared to 23% with placebo

105, Honda, Yasushi, et al

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Some patients lost up to 25 percent of their body weight

Rapid weight loss increases cholesterol secretion into bile, promoting gallstone formation and triggering complications such as cholecystitis or biliary colic