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Levels decline with age , which contributes to thinner skin, slower wound healing, and reduced collagen production

c) Distribution of change in weight in kilograms

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In model systems that mimic these disorders, as well as in emerging human studies, NAD supplementation has demonstrated promising benefits, including improved DNA repair capacity and improved mitochondrial function

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Fernndez-Checa, Liver Unit, Hospital Clnic, Centre Esther Koplowitz, Institut dInvestigacions Biomdiques August Pi i Sunyer (IDIBAPS)Centro de Investigacin Biomdica en Red de Enfermedades Hepticas y Digestivas (CIBERehd), Planta Cuarta, C/Rossell 149, Barcelona 08036, Spain e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a Section of the journal Frontiers in Pharmacology