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Visible improvements usually appear within 812 weeks, with continued enhancement over several months

Beyond systemic symptoms, vitamin B12 deficiency is also associated with a range of oral manifestations, including burning mouth syndrome, recurrent aphthous ulcers, mucosal inflammation, and trigeminal nerve-related pain, which are often underdiagnosed or misattributed to other conditions (Bao et al., 2021

Experimental data show that Pb treatment has a very mild effect on the ABCC3 gene regulatory pathway

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Pathway enrichment analysis demonstrated that these significantly altered metabolites were primarily related to 5 pathways: aspartate metabolism, arginine and proline metabolism, phenylalanine and tyrosine metabolism, urea cycle, cysteine metabolism, and -oxidation of very long chain fatty acids (Fig

Wu G (2009) Amino acids: metabolism, functions, and nutrition