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Oral administration of high-dose vitamin B 12 (1 to 2 mg daily) is considered as effective as intramuscular administration for correcting anemia and neurologic symptoms Despite many studies suggesting oral administration of vitamin B 12 to be easy, effective and less costly than intramuscular administration, debate surrounds the effectiveness of the oral route

Maintaining improvements long-term requires either continued use or transition to lifestyle interventions that sustain AMPK activation (resistance training, caloric cycling)

Hydroxocobalamin regimen (UK example): 1 mg (1000 g) IM three times a week for 2 weeks (loading), then 1 mg every 3 months thereafter

Treatment frequency depends on your individual needs and should be discussed during your consultation

Arch Med Res