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Exposure to pro-oxidant stimuli usually induces Nrf2 activation and upregulation of antioxidant enzyme expression through binding to the antioxidant response element (ARE), localized in the antioxidant enzyme gene promoters
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LC is considered a rate-limiting precursor of glutathione biosynthesis and a physiological antioxidant and anti-inflammatory molecule
This enzyme may fall into the 115 kDa class of large GDH's, however the presence of a functional protein is yet to be shown
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