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Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

doi: 10.1080/23723556.2020.1730144 125 XuDLuYLiYLiSWangZWangJ

10.1038/srep23229 [DOI] [PMC free article] [PubMed] [Google Scholar] 27.De Geyter C

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Lipoic acid was found to upregulate the expression of -GCL and other antioxidant enzymes via the activation of the nuclear factor E2-related factor 2 (Nrf2)-dependent pathway (31, 33)

A immunostained profiles were visualized using diaminobenzidine chromagen