Physiologically, it can bind to GLP-1 receptor on pancreatic beta cells through endocrine, activate adenylate cyclase, increase intracellular cAMP levels, promote glycolysis and ATP production, and enhance glucose-stimulated insulin secretion
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Molestias digestivas (las ms comunes) Nuseas: entre 20% y 44% de los pacientes (ms comn al inicio y con dosis altas) Vmitos: entre 10% y 24% Diarrea: entre 12% y 30% Estreimiento: entre 6% y 24% , segn la molcula y la duracin En general, 4 a 7 de cada 10 pacientes (40-70%) presentan algn sntoma digestivo durante el tratamiento, sobre todo en las primeras semanas, con tendencia a mejorar con el tiempo (1,8-11)
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Molecular weight approximately 340 Da (peptide) + copper ion
Effects of the novel (Pro3)GIP antagonist and exendin(939)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin
