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In the EDICT trial, 221 drug-naive patients with recently diagnosed T2D were randomized to initial simultaneous therapy comprising a combination of agents known to improve insulin secretion and sensitivity (metformin, pioglitazone, and exenatide) or treatment with sequential therapy (i.e., an escalating dose of metformin followed by sequential addition of a sulfonylurea and insulin glargine)
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Based on the saturable metabolism of phenytoin, this may cause phenytoin levels to gradually drift upwards over time (discussed in the section above)
GLP-1 receptor agonist therapy was associated in these cases with reduction or resolution of hypoglycaemic episodes and improvement in dumping-related symptoms
Step 4: Consider the format