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This degradation decreases the Keap1 level in the cytoplasm, relieving its inhibition of Nrf2 and promoting its nuclear translocation and stabilization

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Intestinal disorders and the loss of gut microbiota diversity impair the integrity of the intestinal barrier and can allow harmful microbial products, such as lipopolysaccharides, to enter the bloodstream, leading to systemic inflammation and metabolic disorders, which can weaken muscle function and reduce muscle mass (91) (Figure 3)

Inositol affects insulin signaling and lipid synthesis pathways, though its mechanism remains contested

Available from: This meta-analysis provides an evidence for the effectiveness of selenium supplementation in the context of Keshan disease