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Current perspectives suggest a bidirectional interaction between peripheral immune activation and central inflammation: peripheral inflammation can enhance intracerebral inflammation via the BBB or vagal nerve pathways, while central inflammation can, in turn, stimulate the peripheral immune system (Shin et al., 2022

Furthermore, genome-wide CRISPR screening identified SEC24 homolog B (SEC24B) as a key regulator of ferroptosis, and its knockout significantly inhibited ferroptosis in microglia (Ryan et al., 2023b)

The healthy female subjects were equally randomised into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks

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Navid Noori, Mr

J Indian Chem Soc 100(5):100982