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[PubMed] [Google Scholar] 47.Moskowitz M

Because hemophilia is a rare condition, people with hemophilia may not be well represented in studies that assess the safety of these drugs

Boxed warning: in rodent studies these medications caused thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

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For instance, exenatide, the first GLP-1-analogue developed, demonstrated to promote human monocyte differentiation into alternatively activated M2 macrophages, leading to an increase in anti-inflammatory cytokines such as IL-10 while significantly reducing pro-inflammatory cytokines, including IL-6, TNF- and IL-1 ( Furthermore, GLP-1 has been hypothesised to act as a mediator between innate and adaptive immune responses