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doi: 10.1016/j.cell.2016.03.001 237 RajagopalaSVVasheeSOldfieldLMSuzukiYVenterJCTelentiAet al

Alpha-lipoic acid, vitamin C, and vitamin E are added to enhance its bioavailability

Moreover, higher blood sugar and insulin resistance are well recognized to reduce antioxidants availability

Glucagon receptor agonism Glucagon receptor activation increases energy expenditure, improves liver health, and promotes fat breakdown

Our results further suggest that targeting mitochondrial iron overload or lipid ROS accumulation may represent new cytoprotective strategies for oxidative stress-induced ferroptosis in cardiomyocytes

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