This hypothetical adverse effect, although not clinically reported until now, is analogous to the hypothalamic-pituitary axis suppression seen with long-term use of systemic corticosteroids Exacerbation of Helicobacter pylori associated peptic ulcers: Helicobacter pylori is known to feed on macrophages and neutrophils abundant at the site of inflammation caused by the ulcer
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However, the inherently limited activity of these enzymes in poultry constrains conversion efficiency, explaining why dietary DHA generally produces more robust yolk enrichment than precursor ALA (65)
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