A dose of 2.0 mg was recently approved for diabetes therapy and showed superior HbA 1c and weight reductions and a similar safety profile [41]
GDMT for HFrEF typically includes evidence-based beta-blockers, angiotensin receptor neprilysin inhibitors (ARNIs), angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, mineralocorticoid receptor antagonists (MRA), and sodium-glucose cotransporter 2 inhibitors (SGLT2is), particularly in patients with obesity or T2DM [53]
It has been demonstrated that the expression of the purine-free/pyrimidine-free nucleic acid endonuclease 1 (APE1) is downregulated in gastric host cells infected with H
2025;101(4):762-771.e13
Other reported effects include diarrhea, constipation, bloating and abdominal discomfort
If nausea is pulling you toward soft, sugary foods, try to balance those choices with calcium-rich options like cheese, yogurt, or leafy greens when you can tolerate them