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Experts increasingly expect retatrutide to emerge as a pivotal variable capable of reshaping the market, given that it has repeatedly delivered strong results in clinical studies over the past several years, provided issues such as side effects are improved

There are two malate dehydrogenases in humans encoded by two different genes

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In the SURMOUNT-1 clinical trial, participants on the highest dose of Mounjaro (15 mg) lost an average of 22.5% of their body weight over 72 weeks 1

Acknowledgements The authors would like to thank Xiaotong Zhangs lab at Zhejiang University for the technical support in data acquisition