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GLP-1 medications may significantly reduce fibromyalgia pain and fatigue through anti-inflammatory and neuroprotective mechanisms, but they address underlying drivers rather than offering a permanent cure

Recent studies have evaluated the effects of ocrelizumab in specific CNS structures, such as the thalamus

Meleti M, Leemans CR, Mooi WJ, Vescovi P, van der Waal I

This review delineates the multifaceted mechanisms by which GLP-1RAs exert ocular benefits, including retinal ganglion cell (RGC) rescue via calcium channel and GABAergic modulation, mitochondrial protection through PINK1/Parkin-mediated mitophagy and ERK1/2-HDAC6 signaling, as well as potent anti-inflammatory effects via cytokine reduction and immune cell recruitment inhibition

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According to publicly available information, the PDUFA date for deucravacitinib is September 10, 2022