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The DISC activates caspase 8 (CASP8) or caspase 10 (CASP10) and downstream executioner caspase cascades

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As a ninth example, arginine has a predominant positive net charge below pH~12.0, thus for anion exchange the pH elution gradient with a solvent comprising an organic modifier could begin below pH 12.0 to elute the target GLP-1 moiety and end the gradient above pH 12.0 thereby subsequently removing an undesired form comprising an extra arginine residue