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Additionally, these medicines may influence central nervous system pathways involved in appetite regulation

Many quit after a few months because of cost, side effects or shortages

doi: 10.1016/J.JDIACOMP.2024.108834 101 VarnumAAPozziEDeebelNAEvansAEidNSadeghi-NejadHet al

The American Diabetes Association (ADA) Standards of Care and American College of Physicians (ACP) guidelines support the use of GLP-1 receptor agonists, including dual agonists like tirzepatide, as effective options for glycemic control and weight management

Each additional receptor contributes a distinct metabolic effect: GIP modulates insulin secretion and adipose handling, glucagon contributes to energy expenditure [3][4]