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The complex interaction of factors such as insulin resistance, glucotoxicity and lipotoxicity contribute to the pathogenesis and coexistence of diabetes and metabolic-dysfunction associated steatotic liver disease (MASLD) in a reciprocal process of exacerbating the underlying conditions [9]

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Avoid the skip then eat big pattern and opt for lighter, more consistent intake

A phase 3 go/no-go decision is expected in 2023

Paneth cells respond to inflammation and contribute to tissue regeneration by acquiring stem-like features through SCF/c-kit signaling