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Catalpol synergistically potentiates the anti-tumour effects of regorafenib against hepatocellular carcinoma via dual inhibition of PI3K/Akt/mTOR/NF-B and VEGF/VEGFR2 signaling pathways

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The adverse effects are mainly at the level of biomarkers in blood biochemistry (ALT and AST) or inflammatory biomarkers in kidney tissues (MCP-1, IL-6, TNF-, PAI-1, and resistin)

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The studies concluded that mitigating the higher order aggregates and particulates, decreased immune responses in the rodents tested 18, 19