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It separately lists severe renal disease as a relative contraindication, noting an eGFR under 15 for metformin, and names dehydration risk from both drugs as another reason renal monitoring is treated as standard

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R., Ward S., Hamilton H

Dose-dependent increases in heart rate were also observed, consistent with the glucagon receptor agonism component of the drug, and this warrants careful monitoring in individuals with pre-existing cardiac conditions

Consistent with the notion that GSH per se does not regulate mTORC1 and the ISR, depletion of intracellular GSH exacerbated the loss of mTORC1 signaling upon cystine deprivation, but was without observable effect in the presence of cystine (Fig