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Ongoing challenges to trial conduct include the substances short half-life, the availability of unregulated commercial products, and ensuring protocol compliance

Though implementing these nutritional strategies requires patience and consistency, many patients experience significant symptom improvement over time

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However, these individuals often carry excess abdominal fat or other metabolic risk factors, such that they may not be truly lean

EGFR and c-MET have in common similar downstream pathways: MAPK (RAS/Rapidly accelerating fibrosarcoma (RAF)/ MAP kinase kinases (MEK)/ERK) and PI3K/AKT/mechanistic target of rapamycin (mTOR)

The dual action creates stronger effects on the digestive system, leading to somewhat higher rates of gastrointestinal side effects