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Reference: PubMed Duration in Clinical Research: Supplement doses in prostate research have ranged from 8 mg to 45 mg per day taken over several weeks to months (3 weeks to 6 months) in different trials and reviews

Pain Results: WOMAC Score WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) is the validated instrument for measuring joint pain, stiffness, and function in OA

Xanthine was suggested as an intermediate precursor because of purine structure similarities

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