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1996 (multicenter trial): A larger multicenter, randomized, double-blind, placebo-controlled study enrolled 431 patients with mild to moderate probable Alzheimer's disease, administering 3 g/day of ALCAR for 12 months

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Patients had a 5-week follow-up period after the last dose of the study drug

On the opposite hand, previous studies have also suggested that autophagy may protect against cell necroptosis, while its inhibition may activate and potentiate necroptosis (Matsuzawa-Ishimoto et al., 2017

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