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1-4 PIONEER 4: In a double-blind, double-dummy trial with a primary endpoint of mean change in A1C from baseline to Week 26, 711 adult patients with type 2 diabetes receiving metformin alone or metformin with an SGLT-2i were randomized to semaglutide tablets 14 mg (n=285), liraglutide 1.8 mg subcutaneous injection (n=284), or placebo (n=142), all once daily

Tolerability also depends on your dose trajectory and starting point

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This component typically constitutes a significant portion of the KLOW formulation