The overactivation of microglia leads to the release of pro-inflammatory factors such as Interleukin-1 beta (IL-1), Tumor Necrosis Factor-alpha (TNF- ), and Interleukin-6 (IL-6), which directly damage dopaminergic neurons in the substantia nigra pars compacta (SNpc) (McCarty and Lerner, 2020)
(This is a known side effect for some folks taking high doses of vitamin C.) But even though liposomal vitamin C is absorbed more effectively and may be easier on the GI tract, it still works in the same way as nonliposomal vitamin C once its in your bod
Chan LKM, Braidy N, Ng W, Xu YH, Chen J, McDonald R
IV therapy involves the administration of vitamins, minerals, and other nutrients directly into the bloodstream via an intravenous drip
doi: 10.1093/toxsci/kfj034
Altered smooth muscle cell histone acetylome by the SPHK2/S1P axis promotes pulmonary hypertension