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PMID: 183 ParidaPKMarquez-PalenciaMNairVKaushikAKKimKSudderthJet al

Mechanistically, we show that, upon GSH depletion, the liver tissue induces the expression of target genes associated with the antioxidant transcription factor NRF2

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The resulting Gly-His-Lys-Cu(II) complex shifts the peptide's behavior from a passive ligand to an active modulator of intracellular copper trafficking [2]