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For the remaining seven drugs (Phenylbutazone, Meropenem, Diethylstilbestrol, Prazosin, Enoxacin, Glipizide, and Doripenem), dose responses and heat maps summarizing the dose-response results for the glutathione and senescence assays are presented in Fig

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Similar to other anticancer therapies, ferroptosis-targeting agents may face drug resistance challenges in OS treatment

Moreover, the tumor weight was significantly lighter in the CRC xenografts with SLC25A39 knockdown group compared with the controls (Fig