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In a 2022 study, Santoro found that after 16 weeks of exercise, meal control, and the over-the-counter drug orlistat (Alli), we did not see an improvement in pregnancy rate. In a similar 2016 study in the Netherlands, the weight-loss intervention resulted in a slight decrease in the pregnancy rate

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Glucagon-Like Peptide-1 Induces Cell Proliferation and Pancreatic-Duodenum Homeobox-1 Expression and Increases Endocrine Cell Mass in the Pancreas of Old, Glucose-Intolerant Rats

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2019;29:707718.e8

Mol Psychiatry (2026)