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For GLP-1, the review confirmed insulinotropic effects on -cells during hyperglycaemia, glucagonostatic effects on -cells during hyperglycaemia (indirect, via somatostatin and insulin), gastric emptying delay, CNS appetite suppression, and indirect promotion of lipolysis via increased sympathetic activity

The key to managing side effects is proper dose escalation

For comparison, a major clinical trial published in the New England Journal of Medicine found adults taking semaglutide -- the active ingredient in Wegovy -- lost an average of 14.9% of their body weight over 68 weeks

It is to find an appropriate treatment plan while continuing to monitor your health

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They found widespread associations with benefits to cognitive and behavioral health, while also revealing increased risks for pancreatitis and kidney conditions, among others