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Structural and morphological changes have been reported in humans with depression[92,93]

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doi: 10.1016/bs.ircmb.2022.01.002 7 BruniDAngellHKGalonJ

Although the maximum plasma concentration is lower when compound 2 is administered PO (0.77 M) instead of IP (4.8 M), it is still 4.3-fold higher than LD 50 for ex vivo NTS determined in the commonly used 72 h assay, also indicating that TGR inhibitor 2 is orally bioavailable and the initial prediction of oral bioavailability based on the Lipinski et al