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There is some concern, however, that, while weight loss in obese patients with asthma is associated with improvements in level of lung function and airway responsiveness to inhaled methacholine [61], no significant improvements have been observed in exhaled nitric oxide [62] or other markers of eosinophilic airway inflammation [63]

The stronger goal is to build a supervised plan that helps preserve muscle, reduce metabolic risk, manage side effects, and maintain healthier habits after the most active weight-loss phase slows down

The pre-therapy mean vitamin B12 level in the oral and IV arms was 157 66 picogram/ml and 173 55 picogram/ml (p=0.59 ) respectively and the post-therapy mean vitamin B12 level was 870 348 picogram/ml and 1273 511 picogram/ml (p=0.02 ) respectively [Figure 1]

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That's lower than the 7.1% discontinuation rate seen with semaglutide 2.4 mg in the STEP trials, suggesting tirzepatide is better tolerated at maximum doses despite the higher absolute milligram amount