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It is often studied in preclinical models linked with tissue response, tendon fibroblasts, gut pathways, and angiogenesis

By modulating various metabolic pathways, MOTS-c influences processes such as glucose metabolism, insulin sensitivity, and fat oxidation

BMC Public Health 17 , 683 (2017)

Gut-based strategies to reduce postprandial glycaemia in type 2 diabetes

42 AKT directly and indirectlyby the activation of mTOR, which promotes the stabilization of the transcription factor hypoxia-inducible factor-1stimulates the expression of glucose transporters and key glycolytic enzymes (Figure 3)

N Engl J Med 2016;375(8):794798;